Methods: Chronic pain patients in primary care clinics (N = 250) were randomly assigned to receive 8 weeks of MORE (N = 129) or SG (N = 121). PTSD symptoms were measured using the PTSD Checklist (PCL) at baseline, after treatment, and at 3, 6, and 9 months. Opioid misuse was measured with an objective index triangulating self-report, blinded clinical interview, and drug urine screen. A validated cut-point on the PCL was used to identify participants with PTSD. Linear mixed ANCOVA models with an intent-to-treat approach and maximum likelihood estimation were used to examine the impact of MORE versus SG on PTSD symptoms
Results: Compared to SG, MORE led to significantly lower PTSD symptoms through 9 months of follow-up among the total sample (F[1, 192.3] = 3.9, p = .049). Likewise, MORE was associated with lower levels of PTSD symptoms among participants exceeding a validated cut-point on the PCL for PTSD (F[1, 74.6] = 5.0, p = .029). The effect of MORE on reducing opioid misuse was statistically mediated by decreasing PTSD symptoms, B = -.03, SE = .01, 95% CI = -.06, -.003.
Conclusions and Implications: Our finding demonstrate that MORE was superior to SG for PTSD symptoms among participants generally, as well as among those exceeding a validated cut-point for PTSD. Moreover, these effects mediated the effect of MORE on reducing opioid misuse, and were sustained through 9 months of follow-up. These results provide evidence for the value of MORE as an intervention for addressing PTSD symptomatology in the primary care setting among participants with co-occurring chronic pain and opioid misuseāa vulnerable and clinically complex population.