This roundtable addresses Gender Mainstreaming in the Grand Challenges focused on building a Stronger Social Fabric. These include the Grand Challenges to: Eradicate Social Isolation, End Homelessness, Create Social Responses to a Changing Environment, and Harness Technology for Social Good. Across each of these Grand Challenges, imagining experiences, policies, and practices as gender neutral perpetuates racist, hetero-patriarchal systems of power and privilege. In this roundtable, the authors of the Gender Mainstreaming inserts in the second edition of Grand Challenges book will discuss the importance of an intersectional feminist analysis to identify inequities and promote mechanisms for social change. Specifically, we cannot End Homelessness without identifying housing as a human right and centering the experiences of transgender and nonbinary people. To end homelessness, systems and structures must be redesigned to dismantle gender binaries and create more inclusive services. Harnessing Technology for the Social Good requires going beyond gender-neutrality to actively incorporate the social work values of human dignity and social justice. To reshape technology for positive human benefit, social work must reckon with past harms, identify inequitable systems, and actively seek to reverse technology that serves to maintain and expand disproportionate power structures. To Create Social Responses to a Changing Environment, social work must develop a transformative, intersectional, and feminist response that recognizes that climate change policies imagined as gender-neutral risk exacerbating environmental exposure for women and marginalized communities. Moving social work research and practice beyond gender-neutrality is central to the transformation of inequitable social and institutional structures. Gender Mainstreaming and the Grand Challenges are both mechanisms for social change that can build upon and support one another to build more equitable social structures and stronger social fabric.