Methods: The interdisciplinary ED-LINC intervention team regularly discussed clinical observations and necessary real-time unplanned modifications to the intervention during clinical case conferences. Utilizing the Rapid Assessment Procedure Informed Clinical Ethnography (RAPICE) method, staff reflected on the feasibility, utility, and saliency of the planned and piloted intervention given the current landscape and changing patient needs. As clinician-researchers, the team worked with qualitative content experts to analyze RAPICE reflections and adapt the ED-LINC intervention and study protocol.
Results: From 4/12/2022 to 11/30/2022, 30 patients at Harborview Medical Center were recruited and randomized to the EDLINC intervention. Thematic analysis of RAPICE reflections from this initial sample of intervention participants revealed five domains for adaptation: 1) suicide risk assessment and safety planning, 2) engagement as a targeted piece of intervention, 3) a patient-driven and component-based intervention design, 4) MOUD discussion and approach, and 5) collaborative care framework using measurement-based care. Presented themes informed adaptation of ED-LINC from a stepped-care intervention assuming desire for treatment to a harm-reduction-oriented component-based design anchoring on individualized goal-planning. RAPICE themes also prompted the study team to include innovative fentanyl-based measures in longitudinal outcome data and expanded suicide risk assessment procedures to include specific overdose prevention dimensions.
Conclusions and Implications: The traditional knowledge creation processes in intervention research are proving less effective in a world of rapidly developing crises such as the opioid epidemic. Given the evolving social landscape, the ways of harnessing the clinician-researcher role within teams of investigators who are also involved in direct care deserve additional attention. Rapid assessment procedures like RAPICE provide a structure for making timely adaptations to ensure that study interventions and protocols produce salient and generalizable results.