Findings from three recent studies using innovative approaches to studying clinically relevant topics using virtual reality technology will be presented in this symposium. First, findings from a meta-analytic study examining the potential utility of incorporating virtual simulations that induce cravings into treatment for nicotine cessation will be presented. Despite a number of limitations associated with the studies eligible for inclusion in the meta-analysis (e.g. small sample size), virtual reality technology appears to be a promising avenue that may enhance existing treatments for substance use disorders (Smith, Trahan, Maynard, Khoo, & Farina). Second, a recent prototyping study assessed the extent to which exposure to virtual reality environments are related to physiological and self-report measures of anxiety among combat veterans with social anxiety disorder. The findings of this study indicated that virtual environments may be used to enhance exposure based treatments for disorders such as posttraumatic stress disorder and social anxiety disorder (Metsis, Lawrence, Trahan, Smith, & Tamir). The final presentation will discuss training implications using data from a recent study that examined the feasibility and acceptability of virtual reality to train social work students to perform home visits (McDonald & Davis). The implications of these studies will be discussed along with future recommendations for clinicians and researchers.